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2017
2017 Christmas Dinner with DNA cookies (Thank you Diana)
2017 June - Michael and Nikita leaving drinks, thank you for the work. Good luck in your next positions! Drinks at Castle pub, 16/6/2017
All the best for the future at TTP consulting (MIW) and at Berkley (NH)!
2017 November - Elisa, PhD hat No. XIII, Congratulations! 21/11/2017
All the best for your next job at IBM in Ruschlikon.
2017 May - Jinglin, PhD hat No. XII, Congratulations! Drinks in Brewhouse, 11/5/2017
2017 February - Michael, PhD hat No. XI, Congratulations! Drinks in Red Bull Pub, 24/2/2017
2017 January - Kerstin, PhD hat No. X, Congratulations! 10/1/2017
All the best for the future wherever you will go!
2016
2016 September - Dr Nicholas A. W. Bell, actually left to join the other place! 2/9/2016
All the best for the future - Nick was with us since 2010! Amazing success during 3 years as PhD and Postdoc. We wish that you choose your next projects as wisely as before. Thank you Nick! The group worried about your energy levels ... enjoy ...
2016 September - Karolis, PhD hat No. IX, (first in Maxwell) and viva drinks at Fort St. George, Congratulations! 2/9/2016
All the best for the future - Dr. Misiunas!
2016 June - New group photo and group trip 10-14 June
2016 February - Start of new lunch seminar series - Pizza and science
Room 980A in Rutherford is getting crowded
2016 January - Maria's last day in the Rutherford offices
2016 January - Moving office into the Maxwell
2015
2015 November - Jehangir, PhD hat No. VIII, and viva drinks at Fort St. George, Congratulations! 3/11/2015
"As physicists we are reductionists ..." could be true ...All the best for the future - Dr. Cama!
2015 September - Vivek leaving Dinner at Carpenters Arms 23/10/2015
All the best for the future at EPFL!
2015 June, Irene, Madhavi and Nadanai leaving Dinner Cocum and drinks at Isaac Newton 26/07/2015
All the best for the future at Nottingham, Johns Hopkins and EPFL!
2015 - June, group retreat to Glasgow/Claonaig, Kintyre, Scotland 26-29/6/2015
2015 June - Nadanai, PhD hat No. VII, Congratulations Dr. Laohakunakorn! 19/06/2015
2014 December - Oliver Pambos, PhD "hat" No. VI, Congratulations Dr. Pambos! 15/12/2014
2014 November - Prof Muthukumar leaving drinks Granta Pub 21/11/2014
2014 September - Stefano leaving drinks Granta Pub 26/9/2014
2014 June - Group trip to Barcelona 05/6/2014-09/6/2014
06/06/2014 Talks at Mini-Symposium organised by Miguel Rubi at U Barcelona
06/06/2014 Visit to ICFO
07/06/2014 Journal club and science discussions on the beach
08/06/2014 Some sightseeing
2014 May - Vivek Thacker, PhD hat No. V, viva celebrations at Brewhouse 27/05/2014
2014 May - Making of a PhD hat for Vivek Thacker 26/05/2014
2014 February - Nick Bell, PhD hat No. IV, viva celebrations at Castle 12/02/2014
2013
2013 December - Christmas Bowling and Dinner 12/12/2013
2013 September - Sandip gets a new hat (Sandip leaving dinner) 21/09/2013
2013 September - Leverhulme Lecture 3 16/09/2013
2013 September - Simon Leaving Dinner (Flammkuchen and Kaiserschmarrn) 13/09/2013
2013 August - Group Retreat 23/08/2013
2013 August - "Jana Gana Mana" Dinner for Indian Independence Day 16/08/2013
2013 July - Sandip Leverhulme Lecture (30deg outside) 15/07/2013
2013 May - New football table 31/05/2013
2013 May - Inaugural Cricket evening 20/05/2013
2013 May - Stefano enjoying the one day of summer
2013 Lent Term Dinner 21/3/2013
2012
2012 Christmas Dinner 13/12/2012
2012 Catalin Chimerel, PhD hat No. III, drinks (Castle) 29/10/2012
2012 Spanish Dinner 3/6/2012
2012 Group photo 16/3/2011
2011
2011 Nanopore workshop in London 14/12/2011
2011 Oliver Otto, PhD hat No. II, post viva drinks (Castle) 29/11/2011
2011 Group Trip to Edale 23-25/09/2011
some talks/work
Hiking
2011 Lorenz Steinbock with PhD hat I., drinks at Maypol) 19/09/2011
2011 Lent term dinner 23/03/2011
2011 Birthday Party Stefano and Oliver 26/01/2011
2010
2010 Michaelmas term dinner 26/10/2010
2010 Group Trip Summer school in Berder, France 26/08/2010
2010 Lent term dinner 18/03/2010
Fabian farewell and Oliver's birthday party 19/01/2010
Christmas party 6/12/2009
Dinner Nanosci E+ meeting 22/10/2009
Dinner German general election 27/09/2009
Punting September 2009
Punting with Huppert group July 2009
News
26/7/2023 DNA signals depend on everything.
5/7/2023 DNAo nanocavities.
3/7/2023 July 2023 update.
The Radenovic and Fantner labs at EPFL characterised our DNA carrier systems with controlled nanopipette translocation. Read the full story in Nature Nanotechnology now. Otherwise we are getting ready for the summer conference and workshop season. Yunxuan attended the Faraday discussion on Ionotronics in June. Frank and Ulrich will be in Lyon for the Nanofluidics in Physics and Biology organised by Fabien Montel.
10/6/2023 June 2023 update.
The lab underwent major changes over the last 6 months. Long term members Kaikai Chen and Jinbo Zhu started their own labs back in China. Filip Boskovic defended his PhD thesis and started a delocalised postdoc at HHMI, Harvard and Chicago. Kevin Lim also got a PhD hat and stayed as postdoc in Cambridge. We wish all of them good luck for their start as KeyserLab alumni.
Our push into RNA analysis with nanopore sensing continues with a number of papers published or in preparation in the area. For our work on multiplexed virus detection you can check our recent work in Nature Nanotechnology. In parallel, we also improved the resolution of solid-state nanopore sensing to a few nanometers. You can check out the paper in Advanced Materials.
We also welcome Simon Brauburger as a new PhD student, Jiawen and Jonas as project students.
15/11/2022 November update.
We have a new visiting student: Fei (Frank) joined our nanopore sensing efforts.
18/10/2022 Paper update 2.
14/10/2022 PhD and paper update 1.
Stuart Knowles (former Part III student) of the lab has just defended his PhD thesis. Congratulations and good luck for the future!
11/10/2022 October '22 update.
Robert Novak joins us as MPhil student from the US. Robert will work on ARTEMIS Nature Chemistry with Gerardo Patino Guillen who started his full PhD project within NanoDTC.
We have a few manuscripts that were recently accepted and will share details when they are online.
22/9/2022 September '22 update.
ARTEMIS is finally out in Nature Chemistry. Great work by our PhD student Filip Boskovic. You can check out Filip's work in a nutshell on Twitter or summary from Cavendish website.
Stuart Knowles submitted his PhD thesis and will help Alice Thorneywork to set up her new lab in Oxford. Congratulations to both.
Hein Mante and Meng Siong Chen did a great job during their summer projects with us. Good luck for the future.
We are getting ready for next academic year starting 3rd of October.
21/8/2022 August '22 update.
New work from the lab includes Kareem's work on his GUV studio to measure 1000s of vesicles in parallel. The work in collaboration with Max Ryadnov appeared in Analytical Chemistry. Stuart imaged transport in microfluidic channels and measured the capture of colloidal particles. The work appeared in J. Phys.:Cond. Matter and was led by Alice Thorneywork, who will start her own lab (supported by an ERC Starting Grant) in Oxford in September 2022. Congratulations to all.
We also welcome two summer students Hein Mante (former Part III student) and Meng Siong Chen (UROP funded). Marko Panic is visiting us from Serbia to work on DNA repeats. Welcome!
8/6/2022 June '22 update.
Over the last months we have published Jinbo's work on using split G-quadruplexes to enhance nanopore signals, Jeff's work on 3D optical tracking for optical tweezers, Ran quantified proton transport into OLA vesicles, and Mohammed measured life time of glass nanopores for single molecule sensing.
We also welcome NanoDTC Midi project student Gerardo Patino Guillen.
20/2/2022 February '22 update.
We received a Proof-of-Concept grant from ERC. Contract negotiations ahead. We have published collaborative work with Knowles group on nanofluidic sizing, DNA guided assembly of dye molecules with Auras and Friend groups, and our News & Views on nanopore protein analysis in Science.
We also welcome Hein Mante and Matthew Zhang as Part III students.
9/1/2022 Yunxuan Li joins the KeyserLab. Welcome.
November '21 update Please check out our new papers and preprints in the links below. We were quite busy ...
BioRxiv:
Combination of DNA nanotech and nanopore identification of RNA isoforms
MedRxiv: Detection of SARS-CoV-2 and variants
PRX: Analysis for transition pathes with 'zero' probability in
Chem.Sci.: Controlled aggregation of G-quadruplexes with metalorganic cages from the Nitschke group.
Nano Letters: DNA origami for FRET-based sensing of membrane voltage with the Tinnefeld and Aksimentiev labs
PRL: Polymer adsorption potential revealed with nanopore current noise in a collaboration with Bonthuis led by Thorneywork group.
24/6/2021 Kaikai uses structured DNA nanostrings to reveal polymer physics in nanopores
Kaikai and Nick designed DNA nanostructures that reveal the velocity fluctuations of polymer chains during voltage-driven translocation. Using two types of solid-state nanopores and simulations by the Muthukumar Group at Amherst, the data reveal a two stage translocation process - tension propagation and speed-up. Read the full story in Nature Physics!
18/6/2021 Jinbo developed multi-level barcodes for nanopore image data storage!
Jinbo, Nik and Kaikai designed DNA nanostructures to enhance the data density on our DNA carriers. With our standard 2-bit barcodes serving as address, Jinbo used DNA flowers to encode gray scale image information on our DNA carriers. In addition, encryption of the data is possible! Great advance for nanopores as we read out mixtures of 16 molecules based on enhanced signal-to-noise ratio.
26/5/2021 Soichiro shows that channel length matters for transport!
Diffusion constants in small channels are always higher than the prediction based on conventional modeling. The paper was published in Soft Matter as inside cover article. Soichiro and his co-authors Karolis and Vahe used a combination of experiments, simulations and analytical calculations to develop and test a new model describing diffusivity in short channels. Great results and nice cover!
17/5/2021 Diana defends PhD and gets paper in JACS!
Last Friday Diana successfully defended her PhD thesis. Well done! As Diana is now postdoc in Lausanne at EPFL we only had online viva drinks. Good timing, as her JACS paper on the role of ions on interactions between DNA and lipid membranes is just out now. It was a great collaboration with the Di Michele and Aksimentiev labs! Great work and great results.
27/4/2021 Update for start of Easter term!
Filip and Kaikai developed a method for random access to DNA structural barcodes - published in Small Structures. Check out the paper here. As part of a collaboration led by Max Ryadnov at NPL, Kareem and Marcus have investigated the cytolytic properties of computationally designed antimicrobial peptides with our lab on chip systems, published in ACS nano.
22/2/2021 New students joining the lab!
Part III project student Chengbo Wang will be working on OLA vesicles and analysis with machine learning. Ashleigh Ruane is starting her NanoDTC mini project on nanopore sensing. Yuan (Molly) Shu will be doing her MPhil project in teh next few months. Welcome to the KeyserLab!
8/2/2021 Successful PhD defense of Mustafa!
Mus defended his PhD thesis today. Of course socially distanced through an online viva. Congratulations for completing the PhD (barring the usual small corrections!) Good luck for the future, Dr. Caglar!
4/2/2021 Publications to start the new year!
Welcome to 2021 that hopefully allows us to return to normal. We are still active in the lab! Jinbo and our collaborators from the Nitschke group show that metalorganic cages can be used to tune the kinetics of DNA strand displacement reactions. Check out the nice results in Nano Letters. With our glass nanopores, Kaikai detects small oligo-labels on DNA that were attached by methyltransferases from the Weinhold Lab. Our position resolution approaches a few 10bp nowas shown in ACS nano. Our work on transport through porous 2D materials are put into context in a nice review that Mustafa published in J.Phys.D.
5/10/2020 Sarah and Mohammed join as PhD students. Welcome!
29/9/2020 Jeff defends his PhD thesis
25/9/2020 Nikki moves to Harvard. All the best!
05/8/2020 Summer Update
After the closure of the Cavendish Lab in March 2020 it has finally reopened since Mid June. Despite the lock-down we have published new research:
Diana built a DNA enzyme with lipid flipping rates tuned by structure published in Nano Letters. A collaboration with the Pagliara Lab and others from Exeter - lead by Jehangir - introduces a new Lab Chip system to study drug uptake in single bacteria. Finally, Michael published parts of his finished PhD (congrats!) in BBA-Biomembranes.
We also celebrated the successful completion of three PhDs over the last months with Nik, Michael and Will all now starting life in new (postdoc) jobs. Good luck and thank you very much for your great work!
01/5/2020 Published in Science Advances: Direct detection of molecular intermediates from first-passage times
We show for a diverse range of experimental systems that analysis of dynamics can reveal details of a governing energy landscape, in collaboration with the Bayley group and Ritort group relying on the theoretical analysis by Anatoly Kolomeisky. Great work with great collaborators, Alice!
30/3/2020 Published online in Nano Letters: Nanopore-Based DNA Hard Drives for Rewritable and Secure Data Storage
Kaikai, Jinbo and Filip introduce DNA Hard Drives: rewritable digital storage in DNA that can be read with our solid-state nanopores and easily assembled without synthesis from existing building blocks. In addition without the correct key data cannot be read! Phy.Org featured our work in an excellent article by Anna Demming.
19/3/2020 Published in Applied Materials Today: Aerosol-jet printing facilitates the rapid prototyping of microfluidic devices withversatile geometries and precise channel funct
Kareem and Jehangir worked with the lab of Sohini Kar-Narayan in (Materials) to improve printing of microfluidics. Congratulations!
31/12/2019 Published in ACS nano: Tunable Anion Selective Transport through Mono-Layer Graphene and Hexagonal Boron Nitride
Great end and start to new year! We have shown controllable anion and cation selectivity through monolayer graphene and hexagonal boron nitride and modelled the selective ionic transport. Made possible with a collaboration between HofmannGroup and ZettlGroup.
16/12/2019 Published in PNAS: Optimizing Brownian escape rates by potential shaping
Increasing the height of activation barriers can *accelerate* reactions, rather than slow them down. We show experimentally and theoretically in collaboration with the Trizac lab how Arrhenius/Kramers scaling breaks down for certain barrier shapes. Great work, Jannes and a big thank you to the NanoTrans EU-ITN-training network for funding the work.
28/11/2019 Published in Nanotechnology: Noise properties of rectifying and non-rectifying nanopores
Stuart studied the properties of glass nanopores as components in an ionic circuits, showing that while net conduction is bulk dominated, noise is surface dominated. Great work!
5/11/2019 Published in Nano Letters: All-optical detection of neuronal membrane depolarization in
live cells using colloidal quantum dots
Mus and Raj collaborated with members from the Rao, Greenham and Franze labs to show that neuronal potentials can be detected with calibrated quantum dots. Great!
23/10/2019 Published in Nucleic Acids Research: Controlling aggregation of cholesterol-modified DNA nanostructures
DNA nanopores for lipid membranes just got more versatile as we can now build systems that control aggregation by designed nucleic acid overhangs. Congratulations Alex and a big thank you to the Aksimentiev Lab for MD simulations and Ranson lab for TEM imaging of our small DNA nanostructures!
11/10/2019 Published in Nano Letters: Monitoring G-Quadruplex Formation with DNA Carriers and
Solid-State Nanopores
Filip published part of his MPhil thesis where he uses our glass nanopres for the detection of (un-)folded G-quadruplexes in double-stranded DNA. Congratulations!
11/9/2019 Published in Applied Physics Letters: Cation dependent electroosmotic flow in glass nanopores
Jeff collaborated with Prof Kurt Andresen. We show that cations have unexpected effects on electro-osmotic flows in nanopores. Congrats for being Editor's Pick for issue 11.
26/7/2019 Published in Nano Letters: Current Enhancement in Solid-State Nanopores Depends on Three-Dimensional DNA Structure
Vivian and Nik show that the current enhancement observed in glass nanopores depends on three-dimensional structure of DNA orgiami. Excellent results from Vivian's MPhil project!
8/7/2019 Published online JACS: FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases
Together with the (Nitschke Group) Jinbo shows that their coordination cages are suitable for the all-optical detection of unpaired bases in DNA. Congratulations!
1/7/2019 NEW paper in Phys. Rev. Lett.: Nonlinear Electrophoresis of Highly Charged Nonpolarizable Particles
In a successful collaboration with Douwe Bonthuis (Graz) Soichiro shows that non-linear electrophoresis is real and can lead to a new way of trapping particles beyong dielectrophoresis. Congratulations!
30/5/2019 NEW paper in Phys. Rev. Lett.: Density-Dependent Speed-up of Particle Transport in Channels
Karolis uses hydrodynamic and electrophoretic forces to understand and model stochastic transport in single-file channels. A video explaining the experiments can be found here. Congratulations!
11/02/2019 Just published in Lab on a Chip:
Kareem and our collaborators from NPL and Delft introduce a novel platform for the characterisation of animicrobial peptides in Lab on a Chip!
4/1/2019 For the new year we just published our first paper in Nature Communications: Experimental evidence of symmetry breaking of transition-path times
In a collaboration with Felix Ritort, Jannes showed that transition-path times can be investigates and their symmetry broken in mesoscopic and microscopic systems. Congratulations!
27/12/2018 Just published in Nano Letters: Digital Data Storage Using DNA Nanostructures and Solid-State Nanopores
Kaikai, Jinglin, Jinbo and Nik show their new approach for data storage using nanopore sensing with DNA carriers. Highlighted here on Nanowerk!
27/11/2018 Just published in Adv. Func. Mat.: Two-step sensing enhanced nanopore sensing.
Jinglin, Kaikai and Jinbo show their new approach for nanopore sensing with DNA carriers. Congratulations!
8/10/2018 Ran Tivony, Marcus Fletcher, Stuart Knowles and Filip Boskovic join the lab. Welcome.
21/09/2018 New Part III projects! Check out the selection of our exciting Part III projects for the academic year starting October 2018. If you are interested please get in touch with Ulrich (ufk20 (at) cam.ac.uk).
21/06/2018 Just published in Nature Comm.: An artificial structure made from DNA flips lipids at record rates.
Alex published his work on an artificial enzyme that flips lipids in biological membranes. For more details on our journey from idea to the paper check out Alex' blog post. Congrats Alex and a big thank you goes to everybody in the Aksimentiev Group at Urbana-Champaign for the great collaboration!
02/06/2018 Just published in Nano Letters: Machine learning for complex nanopore data.
Karolis and Nik published their work on neuronal nets for DNA barcode analysis in Nano Letters. QuipuNet can analyze even folded data and increases the number of events by a factor of 5. Congratulations!
21/05/2018 PhD hat for Yizhou. Congratulations.
12/2/2018 New paper on voltage sensing with DNA origami out in
12/1/2018 Alex Ohmann wins Poster Prize at Cavendish Research Day Congratulations!
1/10/2017 Nikki Weckman, Diana Sobota, and Adrian Leathers join the lab. Welcome.
14/12/2016 Abdus Salam price for PhD work of Kerstin Goepfrich.
30/11/2016 NanoDTC associate status for Niklas Ermann
22/6/2016 Building an ion channel out of a single DNA double helix. (Nano Letters)
26/11/2016 PhD student Kerstin Goepfrich tests the MinION sequencer for BBC radio programme
4/4/2016 DNA carriers enable multiplexed protein detection published in Nature Nanotechnology
15/7/2015Nondecaying hydrodynamic interactions published in Physical Review Letters
20/4/2014 Auxetic nuclei in embryonic stem cells published in Nature Materials
Stefano's work on probing the mechanical properties of nuclei in embryonic stem cells was published. We show that the nucleus expands when stretched and compacts when compressed, proving that natural systems can have negative Poisson ratio. OPur work was highlighted by several journals.
News and Views by Ning Wang: nature materials
Highlighted in Science: Editor's choice
7/11/2013 Goepfrich et al. make DNA based nanostructures that act like ion channels in lipid membranes.
Web coverage:
azonano , e!science , sciencedaily , eurekalert , cambridgenetwork , phys.org
4/6/2013 Work on DNA origami nanopores by Silvia Hernandez Ainsa published in ACS nano
22/4/2013 Work of Li, Bell et al. on Protein detection ACS nano highlighted on NanoWerk
Tina and Nick show experiments on detecting proteins in glass nanopores and discuss the various challenges of the technique.
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