We are a group of scientists at the Cavendish Lab, University of Cambridge, UK. Our research is focused on understanding transport processes through membranes.
The physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level is of particular interest. We exert maximum control over all parameters in our experiments using several techniques: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics, often in combination.
Our interdisciplinary team combines researchers with expertise in physics, engineering, physical chemistry, biochemistry/biology, and micro- and nanofabrication.
In case you are interested in working with us, please get in touch with Ulrich by email: ufk20 (at) cam.ac.uk.
We gratefully acknowledge funding of our work from various sources including:
8/6/2022 June '22 update.
Over the last months we have published Jinbo's work on using split G-quadruplexes to enhance nanopore signals, Jeff's work on 3D optical tracking for optical tweezers, Ran quantified proton transport into OLA vesicles, and Mohammed measured life time of glass nanopores for single molecule sensing.
We also welcome NanoDTC Midi project student Gerardo Patino Guillen.
20/2/2022 February '22 update.
We received a Proof-of-Concept grant from ERC. Contract negotiations ahead. We have published collaborative work with Knowles group on nanofluidic sizing, DNA guided assembly of dye molecules with Auras and Friend groups, and our News & Views on nanopore protein analysis in Science.
We also welcome Hein Mante and Matthew Zhang as Part III students.
9/1/2022 Yunxuan Li joins the KeyserLab. Welcome.
November '21 update Please check out our new papers and preprints in the links below. We were quite busy ...
BioRxiv: Combination of DNA nanotech and nanopore identification of RNA isoforms
MedRxiv: Detection of SARS-CoV-2 and variants
PRX: Analysis for transition pathes with 'zero' probability in
Chem.Sci.: Controlled aggregation of G-quadruplexes with metalorganic cages from the Nitschke group.
Nano Letters: DNA origami for FRET-based sensing of membrane voltage with the Tinnefeld and Aksimentiev labs
ACS Synth. Biol. OLA vesicles filtered on chip for artificial cells
PRL: Polymer adsorption potential revealed with nanopore current noise in a collaboration with Douwe Bonthuis led by Alice Thorneywork.
Nano Letters: Nicks or no nicks for DNA based ion channels with our friends from Aksimentiev lab.