KeyserLab

Who we are

We are a group of scientists at the Cavendish Lab, University of Cambridge, UK. Our research is focused on understanding transport processes through membranes for biosensing applications.

The physics of ions, macromolecules and particles in confined geometries at the single molecule level is of particular interest. We exert maximum control over all parameters in our experiments using several techniques: Nucleic acid self-assembly of both RNA and DNA, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, micro-/nanofluidics, often in combination.

Our interdisciplinary team combines researchers with expertise in physics, engineering, physical chemistry, biochemistry/biology, and micro- and nanofabrication.

In case you are interested in working with us, please get in touch with Ulrich by email: ufk20 (at) cam.ac.uk.

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We gratefully acknowledge funding of our work from various sources including:

News

18/10/2022 Paper update 2.

Jinbo constructed parallel autocatalytic DNA circuits. Combined with the nanopore readout a pathway to parallel DNA computing seems possibel. Read the details in his article in Nanoscale. Jinbo designed the project and is leading and corresponding author. Great work.

As part of the DNA-Fairylights consortium Casey and Max have contributed to a review and perspective on DNA data storage. The review concentrates on data storage in DNA sequence and 3D structure including read outs including our solid-state nanopores. It just appeared in ACS nano.

14/10/2022 PhD and paper update 1.
Stuart Knowles (former Part III student) of the lab has just defended his PhD thesis. Congratulations and good luck for the future!

Marcus and Ran have developed a method based on DNA G-quadruplexes to quantify ion transport into lipid vesicles. The work appeared this week in ACS nano in collaboration with the Di Michele Lab. Ran is the last and corresponding author. Congratulations.

11/10/2022 October '22 update.
Robert Novak joins us as MPhil student from the US. Robert will work on ARTEMIS Nature Chemistry with Gerardo Patino Guillen who started his full PhD project within NanoDTC.

We have a few manuscripts that were recently accepted and will share details when they are online.

22/9/2022 September '22 update.
ARTEMIS is finally out in Nature Chemistry. Great work by our PhD student Filip Boskovic. You can check out Filip's work in a nutshell on Twitter or summary from Cavendish website.

Stuart Knowles submitted his PhD thesis and will help Alice Thorneywork to set up her new lab in Oxford. Congratulations to both.

Hein Mante and Meng Siong Chen did a great job during their summer projects with us. Good luck for the future.

We are getting ready for next academic year starting 3rd of October.

21/8/2022 August '22 update.
New work from the lab includes Kareem's work on his GUV studio to measure 1000s of vesicles in parallel. The work in collaboration with Max Ryadnov appeared in Analytical Chemistry. Stuart imaged transport in microfluidic channels and measured the capture of colloidal particles. The work appeared in J. Phys.:Cond. Matter and was led by Alice Thorneywork, who will start her own lab (supported by an ERC Starting Grant) in Oxford in September 2022. Congratulations to all.

We also welcome two summer students Hein Mante (former Part III student) and Meng Siong Chen (UROP funded). Marko Panic is visiting us from Serbia to work on DNA repeats. Welcome!