We are a group of scientists at the Cavendish Lab, University of Cambridge, UK. Our research is focused on understanding transport processes through membranes.
The physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level is of particular interest. We exert maximum control over all parameters in our experiments using several techniques: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics, often in combination.
Our interdisciplinary team combines researchers with expertise in physics, engineering, physical chemistry, biochemistry/biology, and micro- and nanofabrication.
In case you are interested in working with us, please get in touch with Ulrich by email: ufk20 (at) cam.ac.uk.
We gratefully acknowledge funding of our work from various sources including:
22/9/2022 September '22 update.
ARTEMIS is finally out in Nature Chemistry. Great work by our PhD student Filip Boskovic. You can check out Filip's work in a nutshell on Twitter or summary from Cavendish website.
Stuart Knowles submitted his PhD thesis and will help Alice Thorneywork to set up her new lab in Oxford. Congratulations to both.
Hein Mante and Meng Siong Chen did a great job during their summer projects with us. Good luck for the future.
We are getting ready for next academic year starting 3rd of October.
21/8/2022 August '22 update.
New work from the lab includes Kareem's work on his GUV studio to measure 1000s of vesicles in parallel. The work in collaboration with Max Ryadnov appeared in Analytical Chemistry. Stuart imaged transport in microfluidic channels and measured the capture of colloidal particles. The work appeared in J. Phys.:Cond. Matter and was led by Alice Thorneywork, who will start her own lab (supported by an ERC Starting Grant) in Oxford in September 2022. Congratulations to all.
We also welcome two summer students Hein Mante (former Part III student) and Meng Siong Chen (UROP funded). Marko Panic is visiting us from Serbia to work on DNA repeats. Welcome!
8/6/2022 June '22 update.
Over the last months we have published Jinbo's work on using split G-quadruplexes to enhance nanopore signals, Jeff's work on 3D optical tracking for optical tweezers, Ran quantified proton transport into OLA vesicles, and Mohammed measured life time of glass nanopores for single molecule sensing.
We also welcome NanoDTC Midi project student Gerardo Patino Guillen.
20/2/2022 February '22 update.
We received a Proof-of-Concept grant from ERC. Contract negotiations ahead. We have published collaborative work with Knowles group on nanofluidic sizing, DNA guided assembly of dye molecules with Auras and Friend groups, and our News & Views on nanopore protein analysis in Science.
We also welcome Hein Mante and Matthew Zhang as Part III students.