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Physics of Membrane Transport
Single Molecules
Single Particles

Ulrich F. Keyser et al.

Open postdoc position

Research

Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.

We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information TENTATIVE projects below. At the moment we have an opening for a postdoctoral researcher interested in creating artificial ion channels.

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Recent Publications

K. Goepfrich, T. Zettl, A. E. C. Meijering, S. Hernandez-Ainsa, S. Kocabey, T. Liedl, and U. F. Keyser.
DNA-Tile Structures Induce Ionic Currents through Lipid Membranes
.
Nano Letters
, ASAP, 2015. [ DOI | http ]

A. Seifert, K Goepfrich, J. Burns, N. Fertig, U. F. Keyser, and S. Howorka.
Bilayer-spanning DNA nanopores with voltage-switching between open and closed state
.
ACS nano
, 9(2):1117-1126, 2015. [ DOI | http ]

N. A. W. Bell and U. F. Keyser.
Specific Protein Detection using Designed DNA Carriers and Nanopores
.
JACS
, 137(5):2035-2041, 2015. [ DOI | http ]

C.-Y. Li, E. A. Hemmig, J. Kong, J. Yoo, S. Hernandez-Ainsa, U. F. Keyser, and A. Aksimentiev.
Ionic Conductivity, Structural Deformation and Programmable Anisotropy of DNA Origami in Electric Field
.
ACS nano
, 9(2):1420-1433, 2015. [ DOI | http ]

M. I. Walker, R. S. Weatherup, N. A. W. Bell, S. Hofmann, and U. F. Keyser.
Free-standing graphene membranes on glass nanopores for ionic current measurements
.
Appl. Phys. Lett.
, 10:023119, 2015. [ DOI | http ]

S. Pagliara, S. L. Dettmer, and U. F. Keyser.
Channel-facilitated diffusion boosted by particle binding at the channel entrance
.
Phys. Rev. Lett.
, 113:048102, 2014. [ DOI | http ]

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Recent Highlights

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ERC Consolidator Grant for research on novel nanopores. (ERC press release)

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Film explaining DNA origami technology for membrane channels. (Youtube)

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Auxetic nuclei in embryonic stem cells. (Nature Materials)
News and Views by Ning Wang: nature materials
Highlighted in Science: Editor's choice

lipidDNApore

Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor . (Angewandte Chemie)

Press release: U Cambridge
Coverage: azonano , e!science , sciencedaily , eurekalert , cambridgenetwork , phys.org
Hernandez ACS nano highlighted on Genome Web
Li, Bell ACS nano highlighted on NanoWerk