Physics of Membrane Transport
Single Molecules
Single Particles
Ulrich F. Keyser et al.
Our publications
Research
Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.
We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information TENTATIVE projects below.
Recent Publications
N. A. W. Bell, K. Chen, S. Ghosal, M. Ricci, and U. F. Keyser.
Asymmetric dynamics of DNA entering and exiting a strongly
confining nanopore.
Nature Communications, 8(380), 2017.
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K. Chen, M. Juhasz, F. Gularek, E. Weinhold, T. Yu, U. F. Keyser, and N. A. W.
Bell.
Ionic Current-Based Mapping of Short Sequence Motifs in Single
DNA Molecules using Solid-State Nanopores.
Nano Letters, published online, 2017.
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K. Chen, N. A. W. Bell, J. Kong, Y. Tian, and U. F. Keyser.
Direction- and Salt-Dependent Ionic Current Signatures for DNA Sensing with Asymmetric Nanopores.
Biophysical Journal, 112(4):674-682, 2017.
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M. I. Walker, K. Ubych, V. Saraswat, E. A. Chalklen, P. Braeuninger-Weimer,
S. Caneva, R. S. Weatherup, S. Hofmann, and U. F. Keyser.
Extrinsic Cation Selectivity of 2D Membranes.
ACS nano, 11(2):1340-1346, 2017.
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J. Kong, J. Zhu, and U. F. Keyser.
Single Molecule Based SNP Detection Using Designed DNA
Carriers and Solid-State Nanopores.
Chem. Commun., 53:436-439, 2017.
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L. Weller, V. V. Thacker, L. O. Herrmann, E. A. Hemmig, A. Lombardi, U. F.
Keyser, and J. J. Baumberg.
Gap-dependent plasmonic coupling of Ag-Au nanoparticle
heterodimers using DNA origami-based self-assembly.
ACS Photonics, 3(9):1589-1595, 2016.
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K. Göpfrich, C.-Y. Li, I. Mames, S. P. Bhamidimarri, M. Ricci, J. Yoo,
A. Mames, A. Ohmann, M. Winterhalter, E. Stulz, A. Aksimentiev, and U. F.
Keyser.
Ion Channels Made from a Single Membrane-Spanning DNA Duplex.
Nano Letters, 16(7):4665-4669, 2016.
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N. A. W. Bell and U. F. Keyser.
Digitally encoded DNA nanostructures for multiplexed,
single-molecule protein sensing with nanopores.
Nature Nanotechnology, 11:645-651, 2016.
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Recent Highlights
Building an ion channel out of a single DNA double helix. (Nano Letters)
Abdus Salam price for PhD work of Kerstin Goepfrich.
Kerstin was a shared winner of this year's Abdus Salam price for her work on DNA nanopores and channels. Great work and excellent presentation.
Niklas Ermann awarded NanoCDT associate status.
Niklas was admitted to the NanoCDT associates programme which provides additional travel funds. Congratulations.
DNA carriers enable multiplexed protein detection. ( Nature Nanotechnology)
Nondecaying hydrodynamic interactions published in (Physical Review Letters )