Physics of Membrane Transport
Single Molecules
Single Particles

Ulrich F. Keyser et al.

Our publications


Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.

We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information TENTATIVE projects below.

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Recent Publications

M. I. Walker, P. Braeuninger-Weimar, R. S. Weatherup, S. Hofmann, and U. F. Keyser.
Measuring the Proton Selectivity of Graphene Membranes
Appl. Phys. Lett.
, 105:213104, 2015. [ DOI | http ]

J. Cama, H. Bajaj, S. Pagliara, T. Maier, Y. Braun, M. Winterhalter, and U. F. Keyser.
Quantification of fluoroquinolone uptake through the outer membrane channel OmpF of Escherichia coli
, 137(43):13836-13843, 2015. [ DOI | http ]

K. Misiunas, S. Pagliara, E. Lauga, J. R. Lister, and U. F. Keyser.
Non-decaying hydrodynamic interactions along narrow channels
Physical Review Letters
, 115:038301, 2015. [ DOI | http ]

K. Goepfrich, T. Zettl, A. E. C. Meijering, S. Hernandez-Ainsa, S. Kocabey, T. Liedl, and U. F. Keyser.
DNA-Tile Structures Induce Ionic Currents through Lipid Membranes
Nano Letters
, 15(5):3134-3138, 2015. [ DOI | http ]

A. Seifert, K Goepfrich, J. Burns, N. Fertig, U. F. Keyser, and S. Howorka.
Bilayer-spanning DNA nanopores with voltage-switching between open and closed state
ACS nano
, 9(2):1117-1126, 2015. [ DOI | http ]

N. A. W. Bell and U. F. Keyser.
Specific Protein Detection using Designed DNA Carriers and Nanopores
, 137(5):2035-2041, 2015. [ DOI | http ]

C.-Y. Li, E. A. Hemmig, J. Kong, J. Yoo, S. Hernandez-Ainsa, U. F. Keyser, and A. Aksimentiev.
Ionic Conductivity, Structural Deformation and Programmable Anisotropy of DNA Origami in Electric Field
ACS nano
, 9(2):1420-1433, 2015. [ DOI | http ]

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Recent Highlights


Nondecaying hydrodynamic interactions published in (Physical Review Letters )

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ERC Consolidator Grant for research on novel nanopores. (ERC press release)

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Film explaining DNA origami technology for membrane channels. (Youtube)

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Auxetic nuclei in embryonic stem cells. (Nature Materials)
News and Views by Ning Wang: nature materials
Highlighted in Science: Editor's choice