Physics of Membrane Transport
Single Molecules
Single Particles

Ulrich F. Keyser et al.

Our publications


Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.

We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information TENTATIVE projects below.

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Recent Publications

K. Chen, N. A. W. Bell, J. Kong, Y. Tian, and U. F. Keyser.
Direction- and Salt-Dependent Ionic Current Signatures for DNA Sensing with Asymmetric Nanopores
Biophysical Journal
, 112(4):674-682, 2017. [ DOI | http ]

M. I. Walker, K. Ubych, V. Saraswat, E. A. Chalklen, P. Braeuninger-Weimer, S. Caneva, R. S. Weatherup, S. Hofmann, and U. F. Keyser.
Extrinsic Cation Selectivity of 2D Membranes
ACS nano
, 11(2):1340-1346, 2017. [ DOI | http ]

J. Kong, J. Zhu, and U. F. Keyser.
Single Molecule Based SNP Detection Using Designed DNA Carriers and Solid-State Nanopores
Chem. Commun.
, 53:436-439, 2017. [ DOI | http ]

L. Weller, V. V. Thacker, L. O. Herrmann, E. A. Hemmig, A. Lombardi, U. F. Keyser, and J. J. Baumberg.
Gap-dependent plasmonic coupling of Ag-Au nanoparticle heterodimers using DNA origami-based self-assembly
ACS Photonics
, 3(9):1589-1595, 2016. [ DOI | http ]

K. Göpfrich, C.-Y. Li, M. Ricci, S. P. Bhamidimarri, J. Yoo, B. Gyenes, A. Ohmann, M. Winterhalter, A. Aksimentiev, and U. F. Keyser.
Large-Conductance Transmembrane Porin Made from DNA Origami
ACS nano
, 10(9):8207-8214, 2016. [ DOI | http ]

K. Göpfrich, C.-Y. Li, I. Mames, S. P. Bhamidimarri, M. Ricci, J. Yoo, A. Mames, A. Ohmann, M. Winterhalter, E. Stulz, A. Aksimentiev, and U. F. Keyser.
Ion Channels Made from a Single Membrane-Spanning DNA Duplex
Nano Letters
, 16(7):4665-4669, 2016. [ DOI | http ]

N. A. W. Bell and U. F. Keyser.
Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores
Nature Nanotechnology
, 11:645-651, 2016. [ DOI | .html ]

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Recent Highlights

Image 01

Building an ion channel out of a single DNA double helix. (Nano Letters)

Abdus Salam price for PhD work of Kerstin Goepfrich.
Kerstin was a shared winner of this year's Abdus Salam price for her work on DNA nanopores and channels. Great work and excellent presentation.

Niklas Ermann awarded NanoCDT associate status.
Niklas was admitted to the NanoCDT associates programme which provides additional travel funds. Congratulations.

Image 01

DNA carriers enable multiplexed protein detection. ( Nature Nanotechnology)


Nondecaying hydrodynamic interactions published in (Physical Review Letters )