Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.
We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information TENTATIVE projects below.
J. Cama, H. Bajaj, S. Pagliara, T. Maier, Y. Braun, M. Winterhalter, and U. F.
Quantification of fluoroquinolone uptake through the outer membrane channel OmpF of Escherichia coli.
JACS, 137(43):13836-13843, 2015. [ DOI | http ]
K. Goepfrich, T. Zettl, A. E. C. Meijering, S. Hernandez-Ainsa, S. Kocabey,
T. Liedl, and U. F. Keyser.
DNA-Tile Structures Induce Ionic Currents through Lipid Membranes.
Nano Letters, 15(5):3134-3138, 2015. [ DOI | http ]
A. Seifert, K Goepfrich, J. Burns, N. Fertig, U. F. Keyser, and S. Howorka.
Bilayer-spanning DNA nanopores with voltage-switching between open and closed state.
ACS nano, 9(2):1117-1126, 2015. [ DOI | http ]
C.-Y. Li, E. A. Hemmig, J. Kong, J. Yoo, S. Hernandez-Ainsa, U. F. Keyser, and
Ionic Conductivity, Structural Deformation and Programmable Anisotropy of DNA Origami in Electric Field.
ACS nano, 9(2):1420-1433, 2015. [ DOI | http ]
Nondecaying hydrodynamic interactions published in (Physical Review Letters )
ERC Consolidator Grant for research on novel nanopores. (ERC press release)
Film explaining DNA origami technology for membrane channels. (Youtube)