Physics of Membrane Transport
Single Molecules
Single Particles

Ulrich F. Keyser et al.

Our publications


Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.

We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information TENTATIVE projects below.

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Recent Publications

E. A. Hemmig, C. Fitzgerald, C. Maffeo, L. Hecker, S. E. Ochmann, A. Aksimentiev, P. Tinnefeld, and U. F. Keyser.
Optical voltage sensing using DNA origami
Nano Letters
, published online, 2018. [ DOI | http ]

V. Turek, S. Cormier, B. Sierra-Martin, U. F. Keyser, T. Ding, and J. J. Baumberg.
The Crucial Role of Charge in Thermoresponsive-Polymer-Assisted Reversible Dis/Assembly of Gold Nanoparticles
Adv. Optical Mater.
, 2018. [ DOI | http ]

R. Chikkaraddy, V. A. Turek, N. Kongsuwan, F. Benz, C. Carnegie, T. van de Goor, B. de Nijs, A. Demetriadou, O. Hess, U. F. Keyser, and J. J. Baumberg.
Mapping Nanoscale Hotspots with Single-Molecule Emitters Assembled into Plasmonic Nanocavities Using DNA Origami
Nano Letters
, published online, 2017. [ DOI | http ]

C. J. E. Haynes, J. Zhu, C. Chimerel, S. Hernandez-Ainsa, I. A. Riddell, T. K. Ronson, U. F. Keyser, and J. R. Nitschke.
Blockable Zn10L15 ion channels via subcomponent self-assembly
Angewandte Chemie International Edition
, 56(48):15388-15392, 2017. [ DOI | http ]

Y. Tan, L. Dagdug, J. Gladrow, U. F. Keyser, and S. Pagliara.
Particle transport across a channel via an oscillating potential
Phys. Rev. E
, 96:052401, 2017. [ DOI | http ]

N. A. W. Bell, K. Chen, S. Ghosal, M. Ricci, and U. F. Keyser.
Asymmetric dynamics of DNA entering and exiting a strongly confining nanopore
Nature Communications
, 8, 380, 2017. [ DOI | http ]

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Recent Highlights

Image 01

Building an ion channel out of a single DNA double helix. (Nano Letters)

Abdus Salam price for PhD work of Kerstin Goepfrich.
Kerstin was a shared winner of this year's Abdus Salam price for her work on DNA nanopores and channels. Great work and excellent presentation.

Niklas Ermann awarded NanoCDT associate status.
Niklas was admitted to the NanoCDT associates programme which provides additional travel funds. Congratulations.

Image 01

DNA carriers enable multiplexed protein detection. ( Nature Nanotechnology)


Nondecaying hydrodynamic interactions published in (Physical Review Letters )